Chloroacetyl chloride → HCID 57624569, 화합물

HRID 1172868노트

반응식

HRID 1172868 반응식
[CH3:1][O:2][C:3]([C:5]1[S:9][C:8]2[CH:10]=[CH:11][C:12]([NH2:14])=[CH:13][C:7]=2[CH:6]=1)=[O:4].CN1CCOCC1.[Cl:22][CH2:23][C:24](Cl)=[O:25]>C(Cl)Cl.C1COCC1.CCOC(C)=O.O>[Cl:22][CH2:23][C:24]([NH:14][C:12]1[CH:11]=[CH:10][C:8]2[S:9][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][C:7]=2[CH:13]=1)=[O:25]

참가 물질

7

반응물 3

HCID 6577Chloroacetyl chlorideHCID 79724-MethylmorpholineHCID 2824064Methyl 5-amino-1-benzothiophene-2-carboxylate

생성물 1

HCID 57624569HCID 57624569, 화합물

시약·촉매·용매 3

HCID 962Water용매HCID 8857Ethyl Acetate용매HCID 21919333Tetrahydrofurane dichloromethane용매

실험 절차

To a solution of 5-amino-benzo[b]thiophene-2-carboxylic acid methyl ester (989 mg, 4.79 mmol) in CH2Cl2/THF (5/5 mL) was added NMM (630 μL, 5.73 mmol) and chloroacetylchloride (415 μL, 5.25 mmol). After stirring 2.5 h, the mixture was diluted with EtOAc and H2O, and the solid was filtered yielding a pale-white solid, which was used without further purification. MS: cal'd (MH+) 284, exp (MH+) 284.

후처리

  1. filtrationthe solid was filtered
  2. customyielding a pale-white solid, which
  3. customwas used without further purification

출처 및 근거

ORD 기록
ord-670e5bac1978409b8727b163260c22d0
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834034B2

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