Hydroxylamine → HCID 178458441, compound

HRID 1172917Notes

Reaction equation

HRID 1172917 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH:11]([CH3:13])[CH3:12])[C:5]#[N:6].[NH2:14][OH:15]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH:11]([CH3:13])[CH3:12])[C:5]([NH:14][OH:15])=[NH:6]

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 595565423-Chloro-4-isopropoxybenzonitrile

Product 1

HCID 178458441HCID 178458441, compoundYield 98.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

Into a round bottom flask was added 3-chloro-4-isopropoxy-benzonitrile (5.00 g, 25.6 mmol), hydroxylamine (50% by weight in water, 1.86 mL, 28.1 mmol) and ethanol (150 mL). The mixture was heated at about 60° C. overnight. Upon completion of the reaction, the mixture was concentrated to dryness under reduced pressure to give 3-chloro-N-hydroxy-4-isopropoxy-benzamidine (5.76 g, 94%) as a light yellow solid.

Workup

  1. customUpon completion of the reaction
  2. concentrationthe mixture was concentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-9ac6e34e096d415285a50f8a23ebdfab
Source dataset
uspto-grants-2010_11
Patent number
US07834039B2

Reaction notes

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