HRID1173063

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID523102

p-(Trifluoromethoxy)benzenesulphonyl chloride

C7H4ClF3O3S

结构：CCC(=O)N1C[C@@H]2C[C@@H](c3ccc(N)cc3)[C@@H]2C1

HCID67366442

未命名化合物

PRODUCTS

生成物

结构：CCC(=O)N1C[C@@H]2C[C@@H](c3ccc(NS(=O)(=O)c4ccc(OC(F)(F)F)cc4)cc3)[C@@H]2C1

HCID67366262

未命名化合物

收率 86%

PROCEDURE

实验过程

Following a procedure analogous to the procedure described in example 1.5, but starting with 1-[(1R,5S,6R)-6-(4-aminophenyl)-3-aza-bicyclo[3.2.0]hept-3-yl]-propan-1-one and 4-trifluoromethoxybenzensulfonyl chloride, N-[4-((1R,5S,6R)-3-propionyl-3-azabicyclo[3.2.0]hept-6-yl)-phenyl]-4-trifluoromethoxy-benzenesulfonamide (234 mg, yield 86%) was obtained.