HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-(Trifluoromethoxy)benzenesulphonyl chloride → N-[4-((1R,5S,6R)-3-Propionyl-3-aza-bicyclo[3.2.0]hept-6-yl)-phenyl]-4-trifluoromethoxy-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-(Trifluoromethoxy)benzenesulphonyl chloride | HCID 523102 | — |
| Reactant | 1-[(1R,5S,6R)-6-(4-aminophenyl)-3-aza-bicyclo[3.2.0]hept-3-yl]-propan-1-one | HCID 67366442 | — |
| Product | N-[4-((1R,5S,6R)-3-Propionyl-3-aza-bicyclo[3.2.0]hept-6-yl)-phenyl]-4-trifluoromethoxy-benzenesulfonamide | HCID 67366262 | 86% |
Reaction Steps
Following a procedure analogous to the procedure described in example 1.5, but starting with 1-[(1R,5S,6R)-6-(4-aminophenyl)-3-aza-bicyclo[3.2.0]hept-3-yl]-propan-1-one and 4-trifluoromethoxybenzensulfonyl chloride, N-[4-((1R,5S,6R)-3-propionyl-3-azabicyclo[3.2.0]hept-6-yl)-phenyl]-4-trifluoromethoxy-benzenesulfonamide (234 mg, yield 86%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07834048B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-72801e6371154f4a8549dfc54361bac0 |
| Source note | uspto-grants-2010_11 |