反应详情

N-[4-((1R,5S,6R)-3-Propionyl-3-aza-bicyclo[3.2.0]hept-6-yl)-phenyl]-4-trifluoromethoxy-benzenesulfonamide (100 mg, 0.21 mmol) was dissolved in n-butanol (10 ml) followed by the addition of concentrated HCl (2 ml). The solution was refluxed for 3 hours, cooled and concentrated. The residue was washed with ethyl acetate, treated with NaOH (2M) and extracted with ethyl acetate (3×10 ml). The alkaline organic extracts were dried over MgSO4, filtered and concentrated to give N-[4-(3-aza-bicyclo[3.2.0]hept-6-yl)-phenyl]-4-trifluoromethoxy-benzenesulfonamide as an oil (amount 389 mg, yield 98%).

1. temperatureThe solution was refluxed for 3 hours
2. temperaturecooled
3. concentrationconcentrated
4. washThe residue was washed with ethyl acetate
5. additiontreated with NaOH (2M)
6. extractionextracted with ethyl acetate (3×10 ml)
7. dry with materialThe alkaline organic extracts were dried over MgSO4
8. filtrationfiltered
9. concentrationconcentrated