反应详情

A solution of 2-(1,4-dioxaspiro[4.5]dec-8-yl) -1,3-thiazole (0.21 g, 0.93 mmol) in 10 mL of THF/3NHCl (1:1) was stirred for 2 h at 50° C. After cooling to room temperature, the mixture was treated with Na2CO3 to pH 8 and extracted with EtOAc (3×). The combined organic layers were washed with saturated NaCl solution, dried (MgSO4), and concentrated to give 0.16 g of 4-(1,3-thiazol-2-yl)cyclohexanone in 95% yield. MS (EI) calcd: (M+H)+=182.1; found: 181.9.

1. extractionextracted with EtOAc (3×)
2. washThe combined organic layers were washed with saturated NaCl solution
3. dry with materialdried (MgSO4)
4. concentrationconcentrated