反应详情

The product of Step B was dissolved in 20 mL CH2Cl2 and 5.0 mL of a 2 M solution of dimethylamine in tetrahydrofuran was added. The reaction mixture was stirred overnight at room temperature, and then concentrated in vacuo. The residue was partitioned between 50 mL EtOAc, 20 mL water and 10 mL of 5 N sodium hydroxide. The aqueous layer was separated and re extracted with EtOAc, then the organic layers were combined, dried Na2SO4), filtered and evaporated in vacuo to afford the title compound.

1. concentrationconcentrated in vacuo
2. customThe residue was partitioned between 50 mL EtOAc, 20 mL water and 10 mL of 5 N sodium hydroxide
3. customThe aqueous layer was separated
4. extractionre extracted with EtOAc
5. filtrationdried Na2SO4), filtered
6. customevaporated in vacuo