Cyclohexanone → {2-[2-(Benzyloxy)-4,6-di-tert-butylphenyl]ethyl}cyclohexylamine

HRID 1173337Notes

Reaction equation

HRID 1173337 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([C:15]([CH3:18])([CH3:17])[CH3:16])[CH:12]=[C:11]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:10]=1[CH2:23][CH2:24][NH2:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:26]1(=O)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([C:15]([CH3:17])([CH3:16])[CH3:18])[CH:12]=[C:11]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:10]=1[CH2:23][CH2:24][NH:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 7967CyclohexanoneHCID 68714462{2-[2-(Benzyloxy)-4,6-di-tert-butylphenyl]ethyl}amine

Product 1

HCID 68717844{2-[2-(Benzyloxy)-4,6-di-tert-butylphenyl]ethyl}cyclohexylamine

Procedure

The product from Step A (0.227 g) was treated with 0.070 g (0.71 mmol) of cyclohexanone according to the procedure described in Example 3. The product was purified on a silica gel flash chromatography column eluted with 5-10% isopropanol in hexane. Evaporation of the purified fractions and drying in vacuo afforded the title compound.

Workup

  1. customThe product was purified on a silica gel flash chromatography column
  2. washeluted with 5-10% isopropanol in hexane
  3. customEvaporation of the purified fractions
  4. customdrying in vacuo

Sources & evidence

ORD record
ord-4dfe015a8991481bb312a1f3373c367d
Source dataset
uspto-grants-2010_11
Patent number
US07834062B2

Reaction notes

Loading…