4-Hydroxybenzaldehyde → HCID 86623730, compound

HRID 1173389Notes

Reaction equation

[CH:1]1([CH2:4][N:5]([CH2:18][CH2:19][OH:20])[C:6]2[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:7]=2)[CH2:3][CH2:2]1.O[C:22]1[CH:29]=[CH:28][C:25]([CH:26]=[O:27])=[CH:24][CH:23]=1>>[CH:1]1([CH2:4][N:5]([CH2:18][CH2:19][O:20][C:22]2[CH:29]=[CH:28][C:25]([CH:26]=[O:27])=[CH:24][CH:23]=2)[C:6]2[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:16])([F:17])[F:15])[CH:7]=2)[CH2:2][CH2:3]1

Participants

Reactant 2

HCID 1264-Hydroxybenzaldehyde

HCID 11369616HCID 11369616, compound

Product 1

HCID 86623730HCID 86623730, compound

Procedure

Synthesized as described in Example 1C from 4-[(cyclopropylmethyl)(2-hydroxyethyl)amino]-2-(trifluoromethyl)benzonitrile and 4-hydroxybenzaldehyde, then used directly for the step below, step B.

Workup

customSynthesized

Sources & evidence

ORD record: ord-649c31b279fe41ef9fb96be26d438405
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07834063B2

Reaction notes

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