(3-Bromopropoxy)(tert-butyl)dimethylsilane → 4-[(3-Hydroxypropyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

HRID 1173398Notes

Reaction equation

HRID 1173398 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][NH:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.Br[CH2:20][CH2:21][CH2:22][O:23][Si](C(C)(C)C)(C)C>>[OH:23][CH2:22][CH2:21][CH2:20][N:4]([CH2:3][C:2]([F:17])([F:18])[F:1])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:14])[F:15])[CH:6]=1

Participants

3

Reactant 2

HCID 607486(3-Bromopropoxy)(tert-butyl)dimethylsilaneHCID 431385374-((2,2,2-Trifluoroethyl)amino)-2-(trifluoromethyl)benzonitrile

Product 1

HCID 866062484-[(3-Hydroxypropyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Procedure

Synthesized as described in Example 1B from 4-(2,2,2-trifluoro-ethylamino)-2-trifluoromethyl-benzonitrile and [(3-bromopropyl)oxy](1,1-dimethylethyl)dimethylsilane: MS (APCI) m/z 327 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-df99e4762e194b1a9d2b1c7e0ec97d28
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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