Acetaminophen → N-[4-({3-[[4-Cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]propyl}oxy)phenyl]acetamide

HRID 1173399Notes

Reaction equation

HRID 1173399 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][N:5]([CH2:18][C:19]([F:22])([F:21])[F:20])[C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:7]=1.[C:23]([NH:26][C:27]1[CH:32]=[CH:31][C:30](O)=[CH:29][CH:28]=1)(=[O:25])[CH3:24]>>[C:10]([C:9]1[CH:12]=[CH:13][C:6]([N:5]([CH2:18][C:19]([F:20])([F:21])[F:22])[CH2:4][CH2:3][CH2:2][O:1][C:30]2[CH:31]=[CH:32][C:27]([NH:26][C:23](=[O:25])[CH3:24])=[CH:28][CH:29]=2)=[CH:7][C:8]=1[C:14]([F:16])([F:15])[F:17])#[N:11]

Participants

3

Reactant 2

HCID 1983AcetaminophenHCID 866062484-[(3-Hydroxypropyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 11712279N-[4-({3-[[4-Cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]propyl}oxy)phenyl]acetamide

Procedure

Synthesized as described in Example 1C from 4-[(3-hydroxypropyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 4-acetamidophenol: MS (APCI) m/z 460 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-4c730d773c1b4d83a55ab081b5799189
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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