4-Methoxyphenol → HCID 11633101, compound

HRID 1173406Notes

Reaction equation

HRID 1173406 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27](O)=[CH:26][CH:25]=1>>[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([O:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:19])([F:20])[F:21])[C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=2)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 90154-MethoxyphenolHCID 866237314-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 11633101HCID 11633101, compound

Procedure

Synthesized as described in Example 1C using 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 4-methoxyphenol: 1H NMR (300 MHz, CD3OD) δ 7.73 (d, J=9.0 Hz, 1H), 7.36 (d, J=2.3 Hz, 1H), 7.25 (dd, J=9.0 Hz, 2.5 Hz, 1H), 6.80 (app. s, 4H), 4.42 (q, J=8.9 Hz, 2H), 4.17 (t, J=5.1 Hz, 2H), 4.00 (t, J=5.1 Hz, 2H), 3.51 (s, 3H); MS (APCI) m/z 419 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-9d6faabe70c14f6897f54d216a2a57f0
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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