4-(Methylsulfonyl)phenol → HCID 11511035, compound

HRID 1173421Notes

Reaction equation

HRID 1173421 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[CH3:22][S:23]([C:26]1[CH:31]=[CH:30][C:29](O)=[CH:28][CH:27]=1)(=[O:25])=[O:24]>>[CH3:22][S:23]([C:26]1[CH:31]=[CH:30][C:29]([O:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:19])([F:20])[F:21])[C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=2)=[CH:28][CH:27]=1)(=[O:25])=[O:24]

Participants

3

Reactant 2

HCID 1233504-(Methylsulfonyl)phenolHCID 866237314-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 11511035HCID 11511035, compound

Procedure

Synthesized as described in Example 1C from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 4-methanesulfonylphenol: 1H NMR (300 MHz, CDCl3) δ 7.67 (app. d, J=8.8 Hz, 2H), 7.67 (d, J=8.6 Hz, 1H), 7.19 (d, J=2.5 Hz, 1H), 7.05-6.95 (m, 3H), 4.29 (t, J=5.3 Hz, 2H), 4.20 (q, J=8.6 Hz, 2H), 4.05 (t, J=5.1 Hz, 2H), 3.01 (s, 3H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-00a3baace8994ae6b67652991329ddbe
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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