4-Hydroxy-2-methylbenzaldehyde → HCID 86623734, compound

HRID 1173425Notes

Reaction equation

HRID 1173425 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.C[C:23]1[CH:30]=[C:29](O)[CH:28]=[CH:27][C:24]=1[CH:25]=[O:26]>>[CH:25]([C:24]1[CH:27]=[CH:28][C:29]([O:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:19])([F:20])[F:21])[C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=2)=[CH:30][CH:23]=1)=[O:26]

Participants

3

Reactant 2

HCID 4581854-Hydroxy-2-methylbenzaldehydeHCID 866237314-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 86623734HCID 86623734, compound

Procedure

Synthesized as described in Example 1C from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and methyl 4-hydroxybenzaldehyde: 1H NMR (300 MHz, CDC3) δ 9.89 (s, 1H), 7.88-7.80 (m, 2H), 7.68 (d, J=8.9 Hz, 1H), 7.20 (d, J=2.4 Hz, 1H), 7.02 (dd, J=8.8, 2.7 Hz, 1H, partially overlapped with 6.99-6.93), 6.99-6.93 (m, 2H), 4.31 (t, J=5.2 Hz, 2H), 4.20 (q, J=8.5 Hz, 2H), 4.05 (t, J=5.2 Hz, 2H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-157b0bba6d2c459a87080b94590ba0e5
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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