2-Chloro-5-hydroxypyridine → 4-[{2-[(6-Chloro-3-pyridinyl)oxy]ethyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

HRID 1173438Notes

Reaction equation

HRID 1173438 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[Cl:22][C:23]1[N:28]=[CH:27][C:26](O)=[CH:25][CH:24]=1>COCCOC>[Cl:22][C:23]1[N:28]=[CH:27][C:26]([O:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:19])([F:20])[F:21])[C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=2)=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 8198212-Chloro-5-hydroxypyridineHCID 866237314-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 115608994-[{2-[(6-Chloro-3-pyridinyl)oxy]ethyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

Synthesized as described in Example 1C from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 6-chloro-3-pyridinol, using dry DME as reaction solvent: MS (APCI) m/z 424 (M+1).

Workup

  1. customSynthesized
  2. customas reaction solvent

Sources & evidence

ORD record
ord-7f2871739cf84cf28e3952d516382997
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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