HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-hydroxypyridine → 4-[{2-[(6-Chloro-3-pyridinyl)oxy]ethyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-hydroxypyridine | HCID 819821 | — |
| Reactant | 4-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile | HCID 86623731 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 4-[{2-[(6-Chloro-3-pyridinyl)oxy]ethyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile | HCID 11560899 | — |
Reaction Steps
Synthesized as described in Example 1C from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 6-chloro-3-pyridinol, using dry DME as reaction solvent: MS (APCI) m/z 424 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07834063B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-7f2871739cf84cf28e3952d516382997 |
| Source note | uspto-grants-2010_11 |