Neopentylamine → 4-[(2,2-Dimethylpropyl)amino]-2-(trifluoromethyl)benzonitrile

HRID 1173453Notes

Reaction equation

F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1.[CH2:14]([NH2:19])[C:15]([CH3:18])([CH3:17])[CH3:16]>>[CH3:16][C:15]([CH3:18])([CH3:17])[CH2:14][NH:19][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1

Participants

Reactant 2

HCID 79882Neopentylamine

HCID 6050854-Fluoro-2-(trifluoromethyl)benzonitrile

Product 1

HCID 112075814-[(2,2-Dimethylpropyl)amino]-2-(trifluoromethyl)benzonitrile

Procedure

Synthesized as described in Example 1A from 4-fluoro-2-(trifluoromethyl)benzonitrile and neopentylamine: MS (El) m/z 256 (M+, 9%), 239 ({[M−H]—CH3}+, 32%), 199 ([M-tbutyl]+, 78%), 179 ([M-neopentylamine]+, 100).

Workup

customSynthesized

Sources & evidence

ORD record: ord-134e346ce3ec4349af85e6f8e3758dc4
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07834063B2

Reaction notes

Loading…