Acetaminophen → N-[4-({3-[[4-Cyano-3-(trifluoromethyl)phenyl](2,2-dimethylpropyl)amino]propyl}oxy)phenyl]acetamide

HRID 1173455Notes

Reaction equation

HRID 1173455 reaction equation
[CH3:1][C:2]([CH3:22])([CH3:21])[CH2:3][N:4]([CH2:17][CH2:18][CH2:19][OH:20])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[C:23]([NH:26][C:27]1[CH:32]=[CH:31][C:30](O)=[CH:29][CH:28]=1)(=[O:25])[CH3:24]>>[C:9]([C:8]1[CH:11]=[CH:12][C:5]([N:4]([CH2:3][C:2]([CH3:22])([CH3:21])[CH3:1])[CH2:17][CH2:18][CH2:19][O:20][C:30]2[CH:31]=[CH:32][C:27]([NH:26][C:23](=[O:25])[CH3:24])=[CH:28][CH:29]=2)=[CH:6][C:7]=1[C:13]([F:14])([F:15])[F:16])#[N:10]

Participants

3

Reactant 2

HCID 1983AcetaminophenHCID 113475544-[(2,2-Dimethylpropyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 11525160N-[4-({3-[[4-Cyano-3-(trifluoromethyl)phenyl](2,2-dimethylpropyl)amino]propyl}oxy)phenyl]acetamide

Procedure

Synthesized as described in Example 1C from 4-[(2,2-dimethylpropyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile and 4-acetamidophenol: MS (ESI) m/z 448 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-916d6ad87b18423fb80ce87d77e87b73
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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