4-tert-Butylphenol → 4-[(3-{[4-(1,1-Dimethylethyl)phenyl]oxy}propyl)(2,2-dimethylpropyl)amino]-2-(trifluoromethyl)benzonitrile

HRID 1173456Notes

Reaction equation

HRID 1173456 reaction equation
[CH3:1][C:2]([CH3:22])([CH3:21])[CH2:3][N:4]([CH2:17][CH2:18][CH2:19][OH:20])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[C:23]([C:27]1[CH:32]=[CH:31][C:30](O)=[CH:29][CH:28]=1)([CH3:26])([CH3:25])[CH3:24]>>[CH3:24][C:23]([C:27]1[CH:32]=[CH:31][C:30]([O:20][CH2:19][CH2:18][CH2:17][N:4]([CH2:3][C:2]([CH3:22])([CH3:21])[CH3:1])[C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:14])([F:15])[F:16])[CH:6]=2)=[CH:29][CH:28]=1)([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 73934-tert-ButylphenolHCID 113475544-[(2,2-Dimethylpropyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 117119954-[(3-{[4-(1,1-Dimethylethyl)phenyl]oxy}propyl)(2,2-dimethylpropyl)amino]-2-(trifluoromethyl)benzonitrile

Procedure

Synthesized as described in Example 1C from 4-[(2,2-dimethylpropyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile and 4-tert-butylphenol: MS (ESI) m/z 447 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-3a79af01566a40c0817ffa334b860acb
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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