4-Fluorophenol → 4-((2,2-Dimethylpropyl){3-[(4-fluorophenyl)oxy]propyl}amino)-2-(trifluoromethyl)benzonitrile

HRID 1173457Notes

Reaction equation

HRID 1173457 reaction equation
[CH3:1][C:2]([CH3:22])([CH3:21])[CH2:3][N:4]([CH2:17][CH2:18][CH2:19][OH:20])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[F:23][C:24]1[CH:29]=[CH:28][C:27](O)=[CH:26][CH:25]=1>>[CH3:1][C:2]([CH3:22])([CH3:21])[CH2:3][N:4]([CH2:17][CH2:18][CH2:19][O:20][C:27]1[CH:28]=[CH:29][C:24]([F:23])=[CH:25][CH:26]=1)[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:14])([F:15])[F:16])[CH:6]=1

Participants

3

Reactant 2

HCID 97324-FluorophenolHCID 113475544-[(2,2-Dimethylpropyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 115966554-((2,2-Dimethylpropyl){3-[(4-fluorophenyl)oxy]propyl}amino)-2-(trifluoromethyl)benzonitrile

Procedure

Synthesized as described in Example 1C from 4-[(2,2-dimethylpropyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile and 4-fluorophenol: MS (ESI) m/z 409 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-a7f88b88ea44428d8bcf8fc173a3f978
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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