Bromobenzene → 4-[(3-Phenylpropyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

HRID 1173484Notes

Reaction equation

HRID 1173484 reaction equation
[CH2:1]([N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1)[CH:2]=[CH2:3].Br[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:23]1([CH2:3][CH2:2][CH2:1][N:4]([CH2:17][C:18]([F:19])([F:20])[F:21])[C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:14])([F:15])[F:16])[CH:6]=2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 7961BromobenzeneHCID 862395134-[2-Propen-1-yl(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 117107634-[(3-Phenylpropyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Procedure

Synthesized according to Example 84B from 4-[2-propen-1-yl(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and bromobenzene: MS (El) m/z 386 (M+, 6%), 281 (84%), 197 (100%), 170 (76%).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-76dd1651813d4e1bbbbc32a85ead5bc1
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

Loading…