HCID 59556894, compound → HCID 67105492, compound

HRID 1173679Notes

Reaction equation

HRID 1173679 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([N:10]2[CH:14]([CH3:15])[C:13](=[O:16])[C:12]([CH2:19][CH3:20])([CH2:17][CH3:18])[C:11]2=[O:21])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C([BH-](C(CC)C)C(CC)C)(CC)C.[Li+].C1COCC1>>[Cl:1][C:2]1[CH:9]=[C:8]([N:10]2[C@H:14]([CH3:15])[C@H:13]([OH:16])[C:12]([CH2:19][CH3:20])([CH2:17][CH3:18])[C:11]2=[O:21])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 59556894HCID 59556894, compoundHCID 131725857L-SELECTRIDE tetrahydrofuran

Product 1

HCID 67105492HCID 67105492, compound

Procedure

Using 2-chloro-4-(3,3-diethyl-5-methyl-2,4-dioxopyrrolidin-1-yl)benzonitrile (67 mg) and lithium tri(sec-butyl)borohydride-THF solution (0.33 mL, 1 mol/L), and in the same manner as in Example 5, the title compound was obtained as colorless crystals (yield: 34.5 mg, 51%).

Sources & evidence

ORD record
ord-ac6f388063f646b5a30cda207e0c5917
Source dataset
uspto-grants-2010_11
Patent number
US07834051B2

Reaction notes

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