反应详情

Using 4-bromo-2-methoxybenzonitrile (2.34 g), (4R,5S)-3,3-difluoro-4-hydroxy-5-methylpyrrolidin-2-one (2.00 g), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (976 mg), tris(dibenzylideneacetone)dipalladium(0) (504 mg) and cesium carbonate (5.30 g), and in the same manner as in Reference Example 18, the title compound was obtained as a colorless solid (yield: 201 mg, 7%).