反应详情

Using 4-bromo-2-chlorobenzonitrile (615 mg), (4S,5S)-4-hydroxy-4,5-dimethylpyrrolidin-2-one (423 mg), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (241 mg), tris(dibenzylideneacetone)dipalladium(0) (125 mg) and cesium carbonate (1.31 g), and in the same manner as in Reference Example 18, the title compound was obtained as a colorless solid (yield: 431 mg, 60%).