Ethanol → 950483-64-4

HRID 1173766Notes

Reaction equation

HRID 1173766 reaction equation
[CH2:1]([C@H:4]1[O:6][C@@H:5]1[C:7]([O:9]C)=O)[CH2:2][CH3:3].C(O)C.[CH:14]1([NH2:17])[CH2:16][CH2:15]1>C(OCC)(=O)C>[CH:14]1([NH:17][C:7]([C@@H:5]2[C@@H:4]([CH2:1][CH2:2][CH3:3])[O:6]2)=[O:9])[CH2:16][CH2:15]1

Participants

5

Reactant 3

HCID 702EthanolHCID 69828CyclopropylamineHCID 13634376HCID 13634376, compound

Product 1

HCID 24855930950483-64-4Yield 55.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Methyl (2S,3R)-3-propyl-2-oxiranecarboxylate (0.26 g, 1.8 mmol), ethanol (1 ml) and cyclopropylamine (1.03 g, 18 mmol) were mixed, and the mixture was stirred at room temperature for 14 hours. Ethyl acetate (20 ml) was added, and the mixture was washed with 1 N HCl (5 ml) and water (5 ml). The solvent was evaporated away under reduced pressure to obtain the title compound as a pale yellow solid (0.17 g, yield: 55%).

Workup

  1. washthe mixture was washed with 1 N HCl (5 ml) and water (5 ml)
  2. customThe solvent was evaporated away under reduced pressure

Sources & evidence

ORD record
ord-3593dc1e220e49dba87f1cbe42e91e6d
Source dataset
uspto-grants-2010_11
Patent number
US07834190B2

Reaction notes

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