反应详情

The compound (1.47 g) obtained in Example 80-1 was dissolved in anhydrous THF (50 ml). Then, the solution was added with lithium aluminum hydride (671 mg) in an ice bath, followed by stirring at room temperature for 1 hour. After completion of the reaction, the solution was added with methanol and then added with an aqueous potassium sodium tartrate solution, followed by stirring. The solution was extracted with chloroform and the extract was then washed with saturated saline solution. The organic layer was dried with anhydrous sodium sulfate and the solvent was then distilled off, thereby obtaining the subject compound (1.20 g) as a colorless liquid.

1. customAfter completion of the reaction
2. stirringby stirring
3. extractionThe solution was extracted with chloroform
4. washthe extract was then washed with saturated saline solution
5. dry with materialThe organic layer was dried with anhydrous sodium sulfate
6. distillationthe solvent was then distilled off