反应详情

The compound (421.7 mg) obtained in Example 119-1 was dissolved in anhydrous DMF (12.6 ml) and added with potassium phthalimide (663.1 mg), followed by stirring at room temperature for 2 hours. After the reaction, the solvent was distilled off and the residue was then added with water. The mixture was extracted with chloroform and the extract was dried with magnesium sulfate. The solvent was distilled off and the residue was then purified through silica gel column chromatography (chloroform/ethyl acetate), thereby obtaining the subject compound (536.0 mg) as a white solid.

1. customAfter the reaction
2. distillationthe solvent was distilled off
3. additionthe residue was then added with water
4. extractionThe mixture was extracted with chloroform
5. dry with materialthe extract was dried with magnesium sulfate
6. distillationThe solvent was distilled off
7. customthe residue was then purified through silica gel column chromatography (chloroform/ethyl acetate)