Acetophenone → 1-Phenylethanol

Participants

Reaction Conditions

Reaction Steps

Under a nitrogen atmosphere, acetophenone (350 μL, 3.0 mmol) was added to a solution of 1 (11.8 mg, 30 μmol, 1 mol % catalyst) in 5 mL of 2-propanol. The resulting orange solution was stirred at 75° C. for 16 h. After cooling, the solvent was evaporated and the residue was purified by column chromatography (hexanes:ethyl acetate=4:1) to give pure 1-phenylethanol.

Provenance & Evidence