Acetophenone → 1-Phenylethanol

HRID 1174072Notes

Reaction equation

HRID 1174072 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2]>CC(O)C>[C:4]1([CH:1]([OH:3])[CH3:2])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 7410Acetophenone

Product 1

HCID 74091-Phenylethanol

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
75 °C

Procedure

Under a nitrogen atmosphere, acetophenone (350 μL, 3.0 mmol) was added to a solution of 1 (11.8 mg, 30 μmol, 1 mol % catalyst) in 5 mL of 2-propanol. The resulting orange solution was stirred at 75° C. for 16 h. After cooling, the solvent was evaporated and the residue was purified by column chromatography (hexanes:ethyl acetate=4:1) to give pure 1-phenylethanol.

Workup

  1. temperatureAfter cooling
  2. customthe solvent was evaporated
  3. customthe residue was purified by column chromatography (hexanes:ethyl acetate=4:1)

Sources & evidence

ORD record
ord-9c3d0f887bf44d519ae795142dfa2e3d
Source dataset
uspto-grants-2010_11
Patent number
US07834224B1

Reaction notes

Loading…