Trifluoroacetic acid → HCID 67406506, compound

HRID 1174130Notes

Reaction equation

HRID 1174130 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[S:5][CH:6]=[C:7]([CH2:9][N:10]2[CH2:14][CH2:13][N:12]([C@@H:15]([C:23]([CH3:26])([CH3:25])[CH3:24])[C:16]([O:18]C(C)(C)C)=[O:17])[C:11]2=[O:27])[N:8]=1.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>ClCCl>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[CH3:1][O:2][CH2:3][C:4]1[S:5][CH:6]=[C:7]([CH2:9][N:10]2[CH2:14][CH2:13][N:12]([C@@H:15]([C:23]([CH3:25])([CH3:24])[CH3:26])[C:16]([OH:18])=[O:17])[C:11]2=[O:27])[N:8]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67407900HCID 67407900, compound

Product 1

HCID 67406506HCID 67406506, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

A solution containing the product from Example 6G (1.28 g, 3.2 mmol) in dichloromethane (10 mL) was treated with trifluoracetic acid (5 mL), stirred at 25° C. for 4 hours and concentrated. The residue was chromatographed on silica gel eluting with 0-5% methanol in dichloromethane to give the title compound (1.2 g) as the trifluoroacetic acid salt.

Workup

  1. concentrationconcentrated
  2. customThe residue was chromatographed on silica gel eluting with 0-5% methanol in dichloromethane

Sources & evidence

ORD record
ord-18f11ceee6df436f9ca5eca5b9c4156d
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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