反应详情

温度

40 °C

A solution containing the product from Example 10B (10 g, 27.7 mmol) in dichloromethane (100 ml) at −5° C. was slowly treated with an HCl solution in dioxane (200 mL, 4 N), stirred at 40° C. for 6 hrs, stirred at 25° C. for 16 hours concentrated to give the title compound as a hydrochloride salt (10 g, quantitative).

1. stirringstirred at 25° C. for 16 hours
2. concentrationconcentrated