HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1174191Generated: October 30, 2026
Triethylamine → tert-butyl(2S)-2-(2,4-dioxo-1-imidazolidinyl)-3,3-dimethylbutanoate
https://huagongshe.com/reaction/1174191
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-butyl(2S)-2-[(aminocarbonyl)(2-ethoxy-2-oxoethyl)amino]-3,3-dimethylbutanoate | HCID 86598808 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-butyl(2S)-2-(2,4-dioxo-1-imidazolidinyl)-3,3-dimethylbutanoate | HCID 67406589 | 85% |
Reaction Steps
A solution containing the product from Example 46B (20.0 mmol) in methanol (30 mL) was treated with triethylamine (5.6 mL, 40.2 mmol), stirred at 50° C. for 2 hours, and concentrated. The residue was chromatographed on silica gel eluting with 0-30% ethyl acetate/dichloromethane to give the title compound (4.57 g, 85% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07834043B2 |
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| Source dataset | uspto-grants-2010_11 |
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| ORD ID | ord-770ff013f11a410281b60ff83ef47dc7 |
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| Source note | uspto-grants-2010_11 |
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