Trifluoroacetic acid → HCID 61144904, compound

HRID 1174203Notes

Reaction equation

HRID 1174203 reaction equation
[CH3:1][C:2]([CH3:23])([CH3:22])[C@H:3]([NH:11][C:12](=[O:21])[CH2:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:4]([O:6]C(C)(C)C)=[O:5].FC(F)(F)C(O)=O>ClCCl>[CH3:1][C:2]([CH3:23])([CH3:22])[C@H:3]([NH:11][C:12](=[O:21])[CH2:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67408546HCID 67408546, compound

Product 1

HCID 61144904HCID 61144904, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

A solution of the product from Example 54A (0.012 g, 0.038 mmol) in dichloromethane (0.2 mL) was treated with trifluoroacetic acid (0.2 mL) and the reaction was stirred at 25° C. for 1 hour and concentrated. The concentrate was azeotroped with toluene to give the title compound, which was used without further purification.

Workup

  1. concentrationconcentrated
  2. customThe concentrate was azeotroped with toluene

Sources & evidence

ORD record
ord-ab1bff6e309244ef987fa468acafc51e
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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