Trifluoroacetic acid → HCID 59540396, compound

HRID 1174206Notes

Reaction equation

HRID 1174206 reaction equation
[CH3:1][O:2][CH2:3][C:4]([NH:6][C@@H:7]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:8]([O:10]C(C)(C)C)=[O:9])=[O:5].FC(F)(F)C(O)=O>ClCCl>[CH3:1][O:2][CH2:3][C:4]([NH:6][C@@H:7]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:8]([OH:10])=[O:9])=[O:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86598809HCID 86598809, compound

Product 1

HCID 59540396HCID 59540396, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

A solution of the product from Example 55A (0.012 g, 0.038 mmol) in dichloromethane (0.2 mL) was treated with trifluoroacetic acid (0.2 mL), stirred at 25° C. for 1 hour and concentrated. The residue was azeotroped with toluene to give the title compound, which was used without further purification.

Workup

  1. concentrationconcentrated
  2. customThe residue was azeotroped with toluene

Sources & evidence

ORD record
ord-50f423b07ee945839041fb86f430fa58
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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