Methylamine → N-Methyl-1-(2-methyl-1,3-thiazol-4-yl)methanamine

Participants

Reaction Conditions

Reaction Steps

An aqueous solution of methylamine (18 mL, 40%) was treated with the product from Example 109A (2.0 g, 13.5 mmol) in portions over 0.5 hours, stirred at 25° C. for 16 hours, and concentrated. The residue was chromatographed on silica gel eluting with 5% methanol in chloroform to give the title compound (1.23 g, 64% yield).

Provenance & Evidence