Methylamine → N-Methyl-1-(2-methyl-1,3-thiazol-4-yl)methanamine

HRID 1174288Notes

Reaction equation

HRID 1174288 reaction equation
[CH3:1][NH2:2].Cl[CH2:4][C:5]1[N:6]=[C:7]([CH3:10])[S:8][CH:9]=1>>[CH3:1][NH:2][CH2:4][C:5]1[N:6]=[C:7]([CH3:10])[S:8][CH:9]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 7363414-(Chloromethyl)-2-methyl-1,3-thiazole

Product 1

HCID 18939489N-Methyl-1-(2-methyl-1,3-thiazol-4-yl)methanamineYield 64%

Conditions

Temperature
25 °C

Procedure

An aqueous solution of methylamine (18 mL, 40%) was treated with the product from Example 109A (2.0 g, 13.5 mmol) in portions over 0.5 hours, stirred at 25° C. for 16 hours, and concentrated. The residue was chromatographed on silica gel eluting with 5% methanol in chloroform to give the title compound (1.23 g, 64% yield).

Workup

  1. concentrationconcentrated
  2. customThe residue was chromatographed on silica gel eluting with 5% methanol in chloroform

Sources & evidence

ORD record
ord-1e4cc6c617d6428797b55150d1100d17
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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