HCID 42626244, compound → HCID 42625376, compound

HRID 1174321Notes

Reaction equation

HRID 1174321 reaction equation
[C:1]([C:4]1[N:9]=[C:8]([CH2:10][N:11]2[CH2:15][CH2:14][N:13]([C@@H:16]([C:24]([CH3:27])([CH3:26])[CH3:25])[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C:12]2=[O:28])[CH:7]=[CH:6][CH:5]=1)([CH3:3])=[CH2:2]>CO.[Pd]>[CH:1]([C:4]1[N:9]=[C:8]([CH2:10][N:11]2[CH2:15][CH2:14][N:13]([C@@H:16]([C:24]([CH3:25])([CH3:27])[CH3:26])[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C:12]2=[O:28])[CH:7]=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 42626244HCID 42626244, compound

Product 1

HCID 42625376HCID 42625376, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution containing the product from Example 117B (0.038 g, 0.098 mmol) in methanol (1 mL) was treated with 10% Pd on carbon (0.005 g) and the reaction was stirred under an atmosphere of hydrogen (balloon pressure) for 2 hours. The reaction was filtered and the solvent was concentrated to give the title compound, which was used without further purification.

Workup

  1. filtrationThe reaction was filtered
  2. concentrationthe solvent was concentrated

Sources & evidence

ORD record
ord-cb4f92e22ad54f61b2995467a3fc7249
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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