Trifluoroacetic acid → HCID 42626320, compound

HRID 1174347Notes

Reaction equation

HRID 1174347 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][CH:26]=1)[CH2:5][N:6]1[CH2:10][CH2:9][N:8]([C@@H:11]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:12]([O:14]C(C)(C)C)=[O:13])[C:7]1=[O:23].FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][CH:26]=1)[CH2:5][N:6]1[CH2:10][CH2:9][N:8]([C@@H:11]([C:19]([CH3:20])([CH3:21])[CH3:22])[C:12]([OH:14])=[O:13])[C:7]1=[O:23]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67406516HCID 67406516, compound

Product 1

HCID 42626320HCID 42626320, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of Example 137B in dichloromethane (1.5 mL) was treated with trifluoroacetic acid (1.5 mL) at 25° C. for 16 h. The solvents were evaporated, and the crude residue was purified using reverse phase chromatography eluting with a gradient of 95% water (0.1% trifluoroacetic acid)/5% acetonitrile to 100% acetonitrile to give the title compound (0.14 g, 74%).

Workup

  1. customThe solvents were evaporated
  2. customthe crude residue was purified
  3. washeluting with a gradient of 95% water (0.1% trifluoroacetic acid)/5% acetonitrile to 100% acetonitrile

Sources & evidence

ORD record
ord-18e46c50f47c402bbfbb365c3a84d8eb
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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