Trifluoroacetic acid → HCID 67408267, compound

HRID 1174357Notes

Reaction equation

HRID 1174357 reaction equation
[OH:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[CH2:11][CH2:10][N:9]([C@@H:12]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:13]([O:15]C(C)(C)C)=[O:14])[C:8]2=[O:24])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH2:11][CH2:10][N:9]([C@@H:12]([C:20]([CH3:21])([CH3:22])[CH3:23])[C:13]([OH:15])=[O:14])[C:8]2=[O:24])=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67409026HCID 67409026, compound

Product 1

HCID 67408267HCID 67408267, compoundYield 100.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of Example 144B (0.04 g, 0.11 mmol) in dichloromethane (0.5 mL) was treated with trifluoroacetic acid (0.5 mL) at 25° C. for 16 h. The solvents were evaporated, and the crude residue was twice azeotroped with ethyl acetate to give the crude title compound (0.034 g, 100%).

Workup

  1. customThe solvents were evaporated
  2. customthe crude residue was twice azeotroped with ethyl acetate

Sources & evidence

ORD record
ord-1291320a959d45a2a869cd7477060e8a
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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