Hydroxylamine → N-Hydroxy-3-phenylpropanimidamide

HRID 1174480Notes

Reaction equation

HRID 1174480 reaction equation
[C:1]1([CH:7]([CH3:10])C#N)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.NO.[OH:13][N:14]=[C:15]([NH2:22])C1C=CC=CC=1>CCO>[OH:13][N:14]=[C:15]([NH2:22])[CH2:10][CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 787HydroxylamineHCID 157612-PhenylpropionitrileHCID 69186N'-Hydroxybenzenecarboximidamide

Product 1

HCID 53434815N-Hydroxy-3-phenylpropanimidamideYield 70.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Phenylpropionitrile (1 g, 7.6 mmol) was reacted with hydroxylamine (50% in water, 0.94 cm3, 15.2 mmol, 2 eq) in EtOH (7.6 cm3) in the same manner as in the preparation of N′-hydroxybenzimidamide (EtOAc used in extraction) to give the product N′-hydroxy-3-phenylpropanimidamide (0.88 g, 70.5%) as a white solid, mp 42-43° C.

Sources & evidence

ORD record
ord-de61da19bc03412baf9e65d440fc2e9b
Source dataset
uspto-grants-2010_11
Patent number
US07838483B2

Reaction notes

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