Hydroxylamine → HCID 54148817, compound

HRID 1174486Notes

Reaction equation

HRID 1174486 reaction equation
[C:1](#[N:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH2:11][OH:12]>CCO>[OH:12][N:11]=[C:1]([NH2:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 746673-Phenylprop-2-enenitrile

Product 1

HCID 54148817HCID 54148817, compoundYield 70.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Cinnamonitrile (1 g, 7.74 mmol) and hydroxylamine (0.71 cm3, 11.6 mmol, 1.5 eq) were reacted in EtOH (7 cm3) as described for AO6 (two chromatographic separations were needed in purification) to give N′-hydroxycinnamimidamide (0.88 g, 70%) as a light orange solid, mp 85-87° C. (lit 93° C.).

Workup

  1. customas described for AO6 (two chromatographic separations were needed in purification)

Sources & evidence

ORD record
ord-5c4be293ce4c46c8b0395d2c129fb8e1
Source dataset
uspto-grants-2010_11
Patent number
US07838483B2

Reaction notes

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