HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 1H-indole-3-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Indole-3-Acetic Acid | HCID 802 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 1H-indole-3-acetate | HCID 13067 | 158.3% |
Reaction Steps
Indole-3-acetic acid (3.5 g, 20 mmol) was dissolved in ethanol (70 Cm3) and a solution of hydrogen chloride in diethyl ether (12 cm3, 12 mmol) was added. The reaction was heated to reflux for 5 hand upon cooling the solvent was removed under reduced pressure to provide ethyl indole-3-acetate (4 g, 19 mmol, 98%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07838518B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-1d0edb2c960f4da7b5672dd373d319c1 |
| Source note | uspto-grants-2010_11 |