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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1174569Generated: October 31, 2026

Sodium Dithionite → HCID 57525663, compound

https://huagongshe.com/reaction/1174569

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium DithioniteHCID 24489—
ReactantCyclohexane ethylacetateHCID 21867204—
ReactantCarbamic acid, [(3R)-1-[7-(2-butynyl)-2,3,6,7-tetrahydro-3-methyl-1-[2-(2-nitrophenyl)-2-oxoethyl]-2,6-dioxo-1H-purin-8-yl]-3-piperidinyl]-, 1,1-dimethylethyl esterHCID 57525657—
SolventWaterHCID 962—
Solvent2-MethoxyethanolHCID 8019—
ProductHCID 57525663HCID 57525663—

Reaction Steps

Prepared by reduction of 1-[2-(2-nitrophenyl)-2-oxoethyl]-3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butyloxycarbonylamino)piperidin-1-yl]xanthine with sodium dithionite in a mixture of methyl glycol and water (3:2) at 100° C. Rf value: 0.50 (silica gel, cyclohexane/ethyl acetate (4:6)).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07838529B2
Source datasetuspto-grants-2010_11
ORD IDord-f47372e5b3254d239c99a2a4163a1714
Source noteuspto-grants-2010_11