反应详情

A solution of 5-benzyl-2-methyltetrahydropyrrolo[3,4-c]pyrrole-1,3-dione (3.6 g) in THF (15 ml) was added dropwise to a suspension of lithium aluminum hydride (1.68 g) in THF (20 ml) while cooling in ice. The mixture was heated to reflux for 4 hours and then, at 0° C., water (1.8 ml), sodium hydroxide solution (10 M; 1.8 ml) and water (2.5 ml) were cautiously added. The precipitate was filtered off with suction and washed with ethyl acetate. The filtrate was concentrated. The product with the molecular weight of 216.33 (C14H2ON2); MS (ESI): 217 (M+H+) was obtained in this way.

1. temperaturewhile cooling in ice
2. temperatureThe mixture was heated
3. temperatureto reflux for 4 hours
4. filtrationThe precipitate was filtered off with suction
5. washwashed with ethyl acetate
6. concentrationThe filtrate was concentrated
7. customMS (ESI): 217 (M+H+) was obtained in this way