5-Fluoroindole-2-carboxylic acid → HCID 76601345, compound

HRID 1174903Notes

Reaction equation

HRID 1174903 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([OH:13])=O)=[CH:5]2.[CH3:14][N:15]([CH3:31])[CH:16]1[CH2:20][CH2:19][N:18]([C:21]2[S:22][C:23]3[CH:29]=[C:28]([NH2:30])[CH:27]=[CH:26][C:24]=3[N:25]=2)[CH2:17]1>>[CH3:14][N:15]([CH3:31])[CH:16]1[CH2:20][CH2:19][N:18]([C:21]2[S:22][C:23]3[CH:29]=[C:28]([NH:30][C:11]([C:6]4[NH:7][C:8]5[C:4]([CH:5]=4)=[CH:3][C:2]([F:1])=[CH:10][CH:9]=5)=[O:13])[CH:27]=[CH:26][C:24]=3[N:25]=2)[CH2:17]1

Participants

3

Reactant 2

HCID 18205-Fluoroindole-2-carboxylic acidHCID 632315072-(3-Dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-ylamine

Product 1

HCID 76601345HCID 76601345, compoundYield 28%

Procedure

Prepare according to Method B, using 5-fluoroindole-2-carboxylic acid (110 mg, 0.614 mmol) and 2-(3-dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-ylamine (162 mg, 0.618 mmol) to yield the title compound (45 mg, 28%). mass spectrum (m/e): 424 [M+H], 422 [M−H].

Workup

  1. customPrepare

Sources & evidence

ORD record
ord-4eb3e4bcaf8640009a7ceba5fde064a2
Source dataset
uspto-grants-2010_11
Patent number
US07838543B2

Reaction notes

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