2,3-Dichlorobenzeneboronic acid → HCID 11533385, compound

HRID 1174993Notes

Reaction equation

HRID 1174993 reaction equation
[CH3:1][N:2]([CH3:26])[CH2:3][CH2:4][N:5]([CH3:25])[C:6]1[S:7][C:8]2[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][C:16](=[O:24])[C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)[C:9]=2[N:10]=1.[Cl:27][C:28]1[C:33]([Cl:34])=[CH:32][CH:31]=[CH:30][C:29]=1B(O)O>>[CH3:1][N:2]([CH3:26])[CH2:3][CH2:4][N:5]([CH3:25])[C:6]1[S:7][C:8]2[CH:9]=[C:11]([NH:15][C:16]([C:17]3[CH:22]=[CH:21][C:20]([C:32]4[CH:31]=[CH:30][CH:29]=[C:28]([Cl:27])[C:33]=4[Cl:34])=[CH:19][CH:18]=3)=[O:24])[CH:12]=[CH:13][C:14]=2[N:10]=1

Participants

3

Reactant 2

HCID 27346612,3-Dichlorobenzeneboronic acidHCID 68773528HCID 68773528, compound

Product 1

HCID 11533385HCID 11533385, compound

Procedure

The title compound is prepared by following a procedure analogous to Example 113, Step 1, using N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-benzothiazol-yl}-4-iodo-benzamide (0.15 g, 0.31 mmol) and 2,3-dichloro-phenyl boronic acid (0.072 g, 0.38 mmol) to afford 0.13 g (83%). LC/MS, Retention time=5.08 min; (m/z): calcd for C25H24Cl2N4OS: 499.5; found: 499.0.

Workup

  1. customto afford 0.13 g (83%)

Sources & evidence

ORD record
ord-0f483ae3bbaa42d293b3a357905fe7e9
Source dataset
uspto-grants-2010_11
Patent number
US07838543B2

Reaction notes

Loading…