[2-Chloro-4-(trifluoromethyl)phenyl]boronic acid → HCID 11642285, compound

HRID 1174994Notes

Reaction equation

HRID 1174994 reaction equation
[CH3:1][N:2]([CH3:26])[CH2:3][CH2:4][N:5]([CH3:25])[C:6]1[S:7][C:8]2[CH:14]=[C:13]([NH:15][C:16](=[O:24])[C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1.[Cl:27][C:28]1[CH:33]=[C:32]([C:34]([F:37])([F:36])[F:35])[CH:31]=[CH:30][C:29]=1B(O)O>>[CH3:1][N:2]([CH3:26])[CH2:3][CH2:4][N:5]([CH3:25])[C:6]1[S:7][C:8]2[CH:14]=[C:13]([NH:15][C:16]([C:17]3[CH:22]=[CH:21][C:20]([C:29]4[CH:30]=[CH:31][C:32]([C:34]([F:37])([F:36])[F:35])=[CH:33][C:28]=4[Cl:27])=[CH:19][CH:18]=3)=[O:24])[CH:12]=[CH:11][C:9]=2[N:10]=1

Participants

3

Reactant 2

HCID 2783251[2-Chloro-4-(trifluoromethyl)phenyl]boronic acidHCID 57771748N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-benzothiazol-6-yl}-4-iodo-benzamide

Product 1

HCID 11642285HCID 11642285, compound

Procedure

The title compound is prepared by following a procedure analogous to Example 113, Step 1, using N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-benzothiazol-6-yl}-4-iodo-benzamide (0.10 g, 0.21 mmol) and 2-chloro-4-trifluoromethyl-phenyl boronic acid (0.056 g, 0.25 mmol) to afford 0.045 g (40%). LC/MS, Retention time=5.34 min; (m/z): calcd for C26H24ClF3N4OS: 533.0; found: 533.0.

Workup

  1. customto afford 0.045 g (40%)

Sources & evidence

ORD record
ord-dd5eafe8f55442648ab78ad5ef05ebdd
Source dataset
uspto-grants-2010_11
Patent number
US07838543B2

Reaction notes

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