3-Tolylboronic acid → HCID 57771754, compound

HRID 1174996Notes

Reaction equation

HRID 1174996 reaction equation
[CH3:1][N:2]([CH3:26])[CH2:3][CH2:4][N:5]([CH3:25])[C:6]1[S:7][C:8]2[CH:14]=[C:13]([NH:15][C:16](=[O:24])[C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1.[CH3:27][C:28]1[CH:29]=[C:30](B(O)O)[CH:31]=[CH:32][CH:33]=1>>[CH3:1][N:2]([CH3:26])[CH2:3][CH2:4][N:5]([CH3:25])[C:6]1[S:7][C:8]2[CH:14]=[C:13]([NH:15][C:16]([C:17]3[CH:22]=[CH:21][C:20]([C:32]4[CH:31]=[CH:30][CH:29]=[C:28]([CH3:27])[CH:33]=4)=[CH:19][CH:18]=3)=[O:24])[CH:12]=[CH:11][C:9]=2[N:10]=1

Participants

3

Reactant 2

HCID 27339503-Tolylboronic acidHCID 57771748N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-benzothiazol-6-yl}-4-iodo-benzamide

Product 1

HCID 57771754HCID 57771754, compound

Procedure

The title compound is prepared by following a procedure analogous to Example 113, Step 1, using N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-benzothiazol-6-yl}-4-iodo-benzamide (0.10 g, 0.21 mmol) and 3-methyl-phenyl boronic acid (0.037 g, 0.27 mmol) to afford 0.048 g (51%). LC/MS, Retention time=4.96 min; (m/z): calcd for C2H26N4OS (M+H)+: 445.6; found: 445.0.

Workup

  1. customto afford 0.048 g (51%)

Sources & evidence

ORD record
ord-87fc5151567744d1bd3410cebf766c05
Source dataset
uspto-grants-2010_11
Patent number
US07838543B2

Reaction notes

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