2,5-Dichlorobenzeneboronic acid → HCID 57771761, compound

HRID 1174998Notes

Reaction equation

HRID 1174998 reaction equation
[CH3:1][N:2]([CH3:26])[CH2:3][CH2:4][N:5]([CH3:25])[C:6]1[S:7][C:8]2[CH:14]=[C:13]([NH:15][C:16](=[O:24])[C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1.[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][C:29]=1B(O)O>>[CH3:1][N:2]([CH3:26])[CH2:3][CH2:4][N:5]([CH3:25])[C:6]1[S:7][C:8]2[CH:14]=[C:13]([NH:15][C:16]([C:17]3[CH:22]=[CH:21][C:20]([C:32]4[CH:33]=[C:28]([Cl:27])[CH:29]=[CH:30][C:31]=4[Cl:34])=[CH:19][CH:18]=3)=[O:24])[CH:12]=[CH:11][C:9]=2[N:10]=1

Participants

3

Reactant 2

HCID 27733712,5-Dichlorobenzeneboronic acidHCID 57771748N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-benzothiazol-6-yl}-4-iodo-benzamide

Product 1

HCID 57771761HCID 57771761, compound

Procedure

The title compound is prepared by following a procedure analogous to Example 113, Step 1, using N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-benzothiazol-6-yl}-4-iodo-benzamide (0.12 g, 0.25 mmol) and 2,5-dichloro-phenyl boronic acid (0.057 g, 0.30 mmol) to afford 0.098 g, (79%). LC/MS, Retention time=5.29 min; (m/z): calcd for C25H24Cl2N4OS: 499.5; found: 499.0.

Workup

  1. customto afford 0.098 g, (79%)

Sources & evidence

ORD record
ord-d356949a0dd3459b83a69ee4a8a4255a
Source dataset
uspto-grants-2010_11
Patent number
US07838543B2

Reaction notes

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