4-(4-Chlorophenyl)Imidazole → 4-[5-(4-Chloro-phenyl)-imidazol-1-yl]-2,2-dimethyl-2H-chromene-6-carbonitrile

HRID 1175014Notes

Reaction equation

HRID 1175014 reaction equation
[CH3:1][C:2]1([CH3:15])[O:11][C:10]2[C:5](=[CH:6][C:7]([C:12]#[N:13])=[CH:8][CH:9]=2)[CH:4]2O[CH:3]12.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[NH:27][CH:26]=[N:25][CH:24]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[N:27]([C:4]3[C:5]4[C:10](=[CH:9][CH:8]=[C:7]([C:12]#[N:13])[CH:6]=4)[O:11][C:2]([CH3:15])([CH3:1])[CH:3]=3)[CH:26]=[N:25][CH:24]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 4486324-(4-Chlorophenyl)ImidazoleHCID 108673602,2-Dimethyl-3,4-epoxy-6-cyanochroman

Product 1

HCID 160487394-[5-(4-Chloro-phenyl)-imidazol-1-yl]-2,2-dimethyl-2H-chromene-6-carbonitrile

Procedure

Following the procedure in Example 1, using (±)-2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalene-6-carbonitrile and 5-(4-chloro-phenyl)-1H-imidazole as starting materials, the title compounds were prepared as white solid.

Sources & evidence

ORD record
ord-69f4dc1fc1f84ab499178d25b0bb7301
Source dataset
uspto-grants-2010_11
Patent number
US07838553B2

Reaction notes

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